The tumor marker CA242 is defined by the monoclonal antibody C242. The chemical structure of the antigenic determinant is not exactly known, but the determinant have been shown to be a sialylated carbohydrate structure. In serum, CA242 is found on the same mucin-complex as CA50 and sialylated Lewisa (CA19-9). Thus, CA242 is related, but not identical to the epitope of CA19-9 (1, 2). Serum levels of CA242 are low in healthy subjects and subjects with benign diseases, while elevated levels are commonly found in serum from patients with gastro-intestinal cancer (3). The CA242 marker may be used as an aid in the diagnosis and management of patients with known or suspected gastro-intestinal carcinomas (4-9). The CanAg CA242 EIA should not be used as a substitute for any established clinical examination of malignancy, but may be used as a complement to existing clinical and laboratory methods.

SPECIFICATIONS

Results within:

4 hours

Detection limit:

< 1 U/mL

Measuring range:

1 - 150 U/mL
(may be extended by sample dilution)

Sample volume:

25 µL

Hook effect:

No hook up to 150 000 U/mL

Stability:

18 months at 2-8°C

Standard range:

0 - 150 U/mL

Incubation temp:

20 - 28°C

Recovery:

+ 10%

Detection:

620 nm or 405 nm